In the year 1750, Joshua and Naomi Collins, with young son Barnabas, set sail from England to start a new life in America, where they build a fishing empire in the coastal Maine town that comes to carry their name: Collinsport. Two decades pass and Barnabas (Johnny Depp) has the world at his feet. The master of Collinwood Manor, Barnabas is rich, powerful and an inveterate playboy...until he makes the grave mistake of falling in love with a beauty named Josette DuPres (Bella Heathcote) and breaking the heart of Angelique Bouchard (Eva Green). A witch in every sense of the word, Angelique dooms him to a fate worse than death-turning him into a vampire, and then burying him...alive. Nearly two centuries later, Barnabas is inadvertently freed from his tomb and emerges into the very changed world of 1972, a stranger in an even stranger time. Returning to Collinwood Manor, he finds that his once-grand estate has fallen into ruin, and the dysfunctional remnants of the Collins family have fared little better, each harboring their own dark secrets.