Romy and Michele have been roommates since they graduated from a Tucson high school ten years ago. After Romy runs into class curmudgeon and outcast Heather, she learns that their tenth year reunion is fast approaching. Never the popular ones in high school, now Romy and Michele live in L.A. Romy's just a cashier, and Michele is unemployed and both are without boyfriends, so Michele tries to get a job and Romy tries to find boyfriends for them for the reunion. When that doesn't work, the two decide to concoct a wild story about them being successful businesswomen to impress Christie (the class snob) and the other class "A" girls who looked down their noses at the two.